Saxenda Weight Loss Pen | Liraglutide Injection in Pre-filled Pen | Safe and Effective Weight Management | 3ml per pen

Introduction

Saxenda is an injection used for weight loss. It contains the medicine liraglutide. Saxenda® should be used with a reduced calorie diet and increased physical activity.

The drug can be prescribed for people with a body mass index (BMI) over 30. It can also be used for people with a BMI over 27 who have also been diagnosed with weight-related medical problems. These include:

1. Pre-diabetes and diabetes type 2
2. Hypertension (high blood pressure)
3. High cholesterol
4. Obstructive sleep apnoea

About the pen

The parts of the Saxenda® pen are shown below. Please read the Instructions for Use that came with your pen for complete information.

Store new, unused Saxenda® pens in the refrigerator between 36°F and 46°F (2°C to 8°C). After first use, store in a refrigerator or at room temperature between 59°F and 86°F (15°C to 30°C). Pens in use should be thrown away after 30 days even if they still have Saxenda® left in them. Don’t freeze Saxenda®. Saxenda® that has been frozen must not be used.

Treatment Areas

Saxenda® is a once-daily, self-injectable medicine that comes in a prefilled pen. Take your medicine each day at any time that is convenient for you, with or without food. Inject your dose under the skin (this is called subcutaneous injection) in your stomach area (abdomen), upper leg (thigh), or upper arm as instructed by your health care provider. Do not inject into a vein or muscle. 

How Saxenda works?

Saxenda contains the active ingredient liraglutide. Liraglutide is similar to a hormone in the body called glucagon-like peptide-1 (GLP-1). This is an appetite hormone that helps regulate hunger and is released by the intestines after a meal.

Due to being similar to GLP-1, Saxenda regulates appetite causing you to feel fuller and less hungry. This can lead to eating fewer calories and losing weight.

Dose Instruction

Saxenda comes as an injectable pen. The Saxenda pen is injected once daily subcutaneously. The usual injection sites will be the upper arm, upper thigh or abdomen.

The starting dose is a daily injection of 0.6mg. This dose is increased at intervals of usually 1 week until a dose of 3.0mg once daily is reached. An example schedule is shown below:

Week 1 - 0.6mg dose once daily

Week 2 - 1.2mg dose once daily

Week 3 - 1.8mg dose once daily

Week 4 - 2.4mg dose once daily

Week 5 - 3.0mg dose once daily continuing

The dose is gradually increased in 1-week intervals to reduce the chances of stomach side effects like nausea, vomiting and diarrhoea.

If you increase the dose and find the side effects problematic for two weeks or more you should discuss this with your doctor or pharmacist.

Effectiveness

When using Saxenda pens to suppress appetite, you can expect to lose a minimum of 5% of your initial body weight after completing a 12-week course of treatment. You should stop using Saxenda if you have been unable to lose at least 5% of your starting body weight at this time.

In clinical trials of Saxenda, patients saw better results in losing weight when compared to using a placebo injection over 56 weeks. The results are summarised below;

• 63% lost at least 5% of body weight
• 33% lost at least 10% of body weight
• 15% lost at least 15% of body weight

How to inject Saxenda?

Inject your dose of Saxenda® under the skin (subcutaneously) in your stomach area (abdomen), upper leg (thigh), or upper arm, as instructed by your health care provider. Do not inject into a vein or muscle.

Important Safety Information

• Do not share your Saxenda® pen with others even if the needle has been changed. You may give other people a serious infection or get a serious infection from them.

Storage

The unopened box should be stored range from 2℃ to 30℃.

FAQ

1. Who should not use Saxenda®?

Do not use Saxenda® if:

• you or any of your family have ever had MTC or if you have MEN 2.
• you are allergic to liraglutide or any of the ingredients in Saxenda®.
• you are pregnant or plan to become pregnant. Saxenda® may harm your unborn baby.

Before taking Saxenda®, tell your health care provider about all of your medical conditions, including if you:

• are taking certain medicines called GLP-1 receptor agonists.
• have severe problems with your stomach, such as slowed emptying of your stomach (gastroparesis) or problems with digesting food.
• have or have had problems with your pancreas, kidneys or liver.
• have or have had depression or suicidal thoughts, or mental health issues.
• are breastfeeding or plan to breastfeed. It is not known if Saxenda® passes into your breast milk. You and your health care provider should decide if you will use Saxenda® or breastfeed.

2. How much weight can you lose on Saxenda?

The manufacturers of Saxenda say that 3 out of 5 people taking it achieved significant weight loss of 5% or more (meaning an average of 12lb). Their website contains further information on the benefits of Saxenda.

3. How long can you stay on Saxenda?

The duration of treatment should be regularly reviewed by your doctor. It should be stopped if, after 12 weeks on the 3.0mg daily dose, you have not lost at least 5% of your body weight.

4. Do you gain weight after stopping Saxenda?

It is possible to regain weight after stopping Saxenda.

5. Is there any side effects?

Serious side effects may happen in people who take Saxenda®, including:

Possible thyroid tumors, including cancer. Tell your health care professional if you get a lump or swelling in your neck, hoarseness, trouble swallowing, or shortness of breath. These may be symptoms of thyroid cancer. In studies with rats and mice, Saxenda® and medicines that work like Saxenda® caused thyroid tumors, including thyroid cancer. It is not known if Saxenda® will cause thyroid tumors or a type of thyroid cancer called medullary thyroid carcinoma (MTC) in people.

Do not use Saxenda® if you or any of your family have ever had MTC, or if you have an endocrine system condition called Multiple Endocrine Neoplasia syndrome type 2 (MEN 2).

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